Results
| PMID | 16876309 |
| Gene Name | IL15 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 79 |
| Population details | 79 (50 women with endometriosis, 29 fertile women having tubal ligation) |
| Sex | Female |
| Associated genes | IL-15 |
| Other associated phenotypes |
Moderate/ severe endometriosis |
|
Eur J Obstet Gynecol Reprod Biol. 2006 Dec;129(2):169-73. Epub 2006 Jul 28. Lin, Jun| Zhang, Xinmei| Lin, Deng| Fang, Qingxian| Qian, Yuli Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China. xinmei6@yahoo.com OBJECTIVE: To assess the concentrations of interleukin-15 (IL-15) in peritoneal fluid from women with endometriosis and fertile disease-free controls. STUDY DESIGN: Peritoneal fluid samples were obtained from 50 women with endometriosis and 29 fertile women having tubal ligation. Concentrations of IL-15 were measured. RESULTS: The mean (S.D.s) concentration of IL-15 in peritoneal fluid was 11.17 pg/mL (3.89) for women with endometriosis, and 12.59 pg/mL (4.11) for fertile disease-free controls. The difference of peritoneal IL-15 concentrations between endometriosis and control women was not statistically significant. However, peritoneal IL-15 concentrations were significantly lower in women with moderate/severe endometriosis when compared with those in women with minimal/mild endometriosis, and in controls (P<0.05). In addition, peritoneal IL-15 concentrations did not correlate with the phase of menstrual cycle in endometriosis or control women. CONCLUSIONS: Our results suggest that the decreased peritoneal IL-15 concentrations in women with moderate/severe endometriosis imply a role of IL-15 in the pathogenesis of advanced endometriosis as compared to those with minimal/mild endometriosis and fertile disease-free controls. Mesh Terms: Adult| Ascitic Fluid/*chemistry/immunology| Case-Control Studies| Endometriosis/*immunology/surgery| Female| Humans| Interleukin-15/*analysis/immunology/metabolism| Laparoscopy|DA 2007/02/21 09:00 |
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